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Charlie Kaufman writes and co-directs this stop-motion animated comedy drama, based on his own play. The film follows self-help author and motivational speaker Michael Stone (voice of David Thewlis) as he travels to Cincinnati, Ohio to promote his latest book. Despite making his living as an inspirational guide to others, Michael is in the middle of an existential crisis and suffers from an unusual condition where he observes everyone as looking and sounding exactly the same, even his wife and son. When he arrives at his hotel in Cincinnati, Michael miraculously hears a unique female voice again, different from everyone else in the world (Tom Noonan). After rushing to find its owner, he meets Lisa Hesselman (Jennifer Jason Leigh) who he nicknames 'Anomalisa'. After spending the night with one another, Michael proposes the idea of running away together but will Lisa want to join him? The film was nominated for the Academy Award for Best Animated Film.